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A standard chow diet (RM1 (E) 801492, SDS) and tap water were provided ad libitum
Reported effects Significant body weight reduction (10-15% in trials) Improved glycemic control and reduced insulin resistance Reduced appetite and food cravings Potential cardiovascular benefits Convenient once-weekly dosing schedule Reported side effects Gastrointestinal issues (nausea, vomiting, diarrhea, constipation) Injection-site reactions (redness, swelling) Hypoglycemia (especially when combined with other diabetes medications) Rare serious risks: pancreatitis, gallbladder issues, kidney injury Thyroid C-cell tumors (observed in rodents) Storage Lyophilised (unmixed) Freeze at -20 C (-4 F) After reconstitution Refrigerate at 28 C (35.646.4 F), use within 28 days Supplies Important notes Always use a new, sterile insulin syringe for each injection and dispose of it properly in a sharps container
The growing prevalence of metabolic syndrome has only exacerbated these challenges as our transplant recipients either have pre-existing diabetes mellitus and/or mild CKD or develop these conditions post-transplantation
05 Treat any extension as a new decision A 16- or 24-week timeline adds more exposure but does not have proven added value for a subcutaneous schedule
Key takeaways Wegovy injection or tablets can sometimes cause unusual skin sensations like tenderness, burning, tingling, or pain to the touch, though these skin side effects are more common at higher doses
As described previously in this report, combination approaches may be able to target multiple mechanisms simultaneously or sequentially, potentially leading to more effective treatments
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