Monitor how you feel over the next few days
IGF-1 and cancer risk

Contact your healthcare provider if you experience: Severe or persistent cramps that do not respond to self-care measures or significantly impact your quality of life and daily activities Frequent cramping occurring multiple times daily or nightly, disrupting sleep and functioning Associated symptoms including muscle weakness, numbness, tingling, or changes in sensation, which may suggest neurological involvement Swelling, redness, or warmth in the affected leg, which could indicate deep vein thrombosis or other vascular complications Severe gastrointestinal symptoms with signs of dehydration such as decreased urination, dizziness, confusion, or rapid heartbeat Cramps that began after starting semaglutide and persist despite adequate hydration and nutritional measures Seek immediate medical attention (call 911) if you develop: Chest pain, shortness of breath, or severe abdominal pain Signs of severe dehydration including inability to keep down fluids, minimal urine output, or altered mental status Symptoms suggesting acute kidney injury, such as significantly decreased urination, swelling, or confusion Your healthcare provider can perform a comprehensive evaluation including physical examination, review of your medication regimen, and laboratory testing to assess electrolyte levels, kidney function, and other relevant parameters

R.NedaeiniaR.Sepehri ShamlooA.NikdoustS.Kazemi OskueeR
Decreasing serum cholesterol levels as a strategy to support cancer treatments most commonly involves the use of drugs that inhibit mevalonate pathway, and as a result, clinical trials targeting cholesterol metabolism in cancer rely strongly on the inhibition of cholesterol synthesis [133,134,135]
Rizzo agreed that the association of NAION with a drug that is anti-inflammatory, neuroprotective and vasculoprotective is problematic, noting that at present there is no substantive basis for explaining the link between semaglutide and NAION