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It is primarily manifested by increased intracellular iron levels and enhanced lipid peroxidation, ultimately leading to cell death characterized by mitochondrial shrinkage, loss of cristae, and disruption of membrane integrity ( The Gut Microbiota, as a vital component of the intestinal microenvironment, plays a pivotal role in maintaining intestinal homeostasis, modulating host immune responses, participating in metabolic regulation, and promoting nutrient absorption

Therefore, after Fe 2+ is excreted, it is oxidized to Fe 3+ by iron transport auxiliary proteins on the basolateral membrane or by ceruloplasmin, after which the generated pools of Fe 3+ bind with Tf to enter the plasma, forming serum iron, or they are transferred to cells that require iron

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This serum can be applied very lightly around the eye area

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