Furthermore, glutathione is involved in specific functions such as detoxification of heavy metals, transfer and storage of sulfur, regulation of expression of defense-related genes and protein activity, while ascorbate acts as a signal-transducing molecule, cofactor of some enzymes and biosynthetic precursor of oxalic and l-tartaric acids
These findings establish a critical role for GSH in promoting Rickettsia cell division and pathogenesis, contributing to the concept that GSH plays multifaceted roles in the fitness of intracellular pathogens
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