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Data from LEAD-1 and the CORE model show that liraglutide with glimepiride reduces mortality and diabetes-related complications more than rosiglitazone with glimepiride (55)
Increase protein, reduce the dose, or both
This protocol requires the full escalation through 2mg, 4mg, 8mg, and 12mg over 12 to 24 weeks depending on the schedule chosen
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Endocrine markers Baseline concentrations of the endocrine markers at T1 were not significantly different across the four conditions ( p s 0.05, Table S2)
They aren't mutually exclusive -- many patients benefit from both
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