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Furthermore, a study describing the data in the pharmaceutical company safety databases on pregnant women exposed to glucose lowering drugs including SGLT2 inhibitors was found (46)

This requires individualized consideration

ICARUS-Lung01 is a multicentre, single-arm, phase II trial evaluating Dato-DXd in refractory NSCLC (including patients with an actionable genomic alteration) and progressing to at least one line of immunotherapy and platinum-doublet regimen

Specifically, the HR for major depressive disorder is 2.95 (95% CI 2.823.08), for anxiety 2.08 (95% CI 2.042.12), and for suicidal ideations or attempts 2.06 (95% CI 1.922.21), further demonstrating the significant association with GLP-1 RA treatment over time

Free radicals are unstable molecules that contain unpaired electrons, which can cause damage to cells, proteins, and DNA

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