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Comparative Risk: In patients with Type 2 Diabetes, GLP-1 RA use was associated with a 7% lower cancer incidence compared with DPP4 inhibitors
Diabetes drugs like Ozempic can often cause users to lose weight, but this particular medication has not been approved as a safe weight-loss treatment
10.1016/j.ijbiomac.2022.05.109 15 ChenX.ChenC.FuX
Molecularly, PEG Loxenatide was selected from exenatide, with the difference that the 8th position is mutated to D-Ala, and additionally PEGylayted at the cysteine site using lysine as a linker (Figure 3)
Ongoing studies suggest their meaningful clinical benefits in MASLD/MASH, HFpEF, atherosclerotic CVD, and potentially even neurodegenerative disorders
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