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James, S

In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)

Waghray et al., 2005

And while the official guidance says they are all equivalent, the real-world experience of thousands of researchers tells a more nuanced story

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