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The Injection (Subcutaneous) - Dosing: Once weekly - Bioavailability: ~100% (bypasses GI tract) - Weight loss in trials: Up to 22% at 36 weeks - Best for: Patients seeking maximum efficacy, comfortable with self-injection The Pill (Oral) - Dosing: Once daily (taken on an empty stomach, similar to Rybelsus) - Bioavailability: Lower than SC (relies on SNAC absorption technology) - Weight loss in trials: Up to 13.1% at 12 weeks (Phase 1 short duration) - Best for: Injection-averse patients, early treatment, maintenance, broader access The oral formulation will almost certainly deliver less weight loss than the subcutaneous version at equivalent treatment durations
doi: 10.1136/gut.52.6.854 40 BrederC
If you are taking a GLP-1 medication and experience any of these symptoms for more than 24 hours, check in with your doctor
Recommended dosage: 1 capsule per day
As additional biosimilars enter the market in 2026, from inflammatory conditions to oncology and beyond, we anticipate even more savings opportunities for employers who are ready to adopt them
How GLP-1 Medications Support Weight Loss & Metabolic Health GLP-1 (glucagon-like peptide-1) is a hormone your body naturally produces to regulate hunger, digestion, and blood sugar
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