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For patients planning pregnancy, semaglutide should be discontinued at least 2 months before a planned pregnancy due to the long half-life, while tirzepatide may persist for approximately 1 month

In addition, activation of GLP-1R regulates mitochondrial over fission by the cAMP/PKA pathway while improving mitochondrial function in A-treated astrocytes and ameliorating pathological lesions in AD (Xie et al., 2021)

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Neuroinflammation has been identified as a key contributor to the pathobiology of AD [2,3,4] and occurs at early disease stages [2, 5,6,7]

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