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Innate Repair Receptor (IRR) Activation: ARA-290 binds selectively to the IRR (EPOR/CR heteromer), activating the full IRR-mediated tissue protection cascade: JAK2/STAT3, PI3K/Akt, and MAPK/ERK signalling, producing anti-apoptotic, anti-inflammatory, and regenerative downstream effects across neural, vascular, and metabolic cell types
BODIPY- C1-27A labelling of GSTO1 was decreased in C1-27 -treated tumours compared with the control group (Fig
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Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells
A.WicksteedB.AllardC.ZhangG.et al (2016)
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