In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)
Zhao, D., Liu, J., Wang, M., Zhang, X
if it is a confound you are deliberately removing, LR3 is the right reagent and the paper needs to say so
And just as importantly, are the claims being made about them actually allowed
Complementary Mechanisms When combined, these compounds create a multi-faceted approach to NO enhancement: Increased Substrate Availability - As described above, L-citrulline effectively raises plasma L-arginine levels, providing more raw material for nitric oxide synthase (NOS) enzymes to produce NO
10.1146/annurev-biophys-062215-010822 Annu