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By improving insulin sensitivity, GLP-1 agonists can help mitigate the effects of insulin resistance, thereby fostering a more favourable hormonal environment
However, the collected body of evidence does not fully support its clinically relevant antidepressant benefit [165]
However, retatrutide is a first-in-class triple agonist (targeting GIP, GLP-1, and glucagon receptors simultaneously), which may lead to more cautious FDA review compared to drugs with established mechanisms
10.1038/s41380-018-0237-8 117
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used to alleviate pain, can have adverse effects on gut health by disrupting the microbiome and causing inflammation
Food and Drug Administration (FDA) include: semaglutide (Ozempic, Wegovy, Rybelsus) tirzepatide (Mounjaro, Zepbound) liraglutide (Victoza, Saxenda) dulaglutide (Trulicity) exenatide (Byetta, Bydureon) lixisenatide (Adlyxin) Each works a bit differently and is FDA-approved for different uses
