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In stroke, reduced mitophagy and autophagy may hinder the prompt clearance of damaged mitochondria in the brain, leading to a loss of protection from increased reactive oxygen species (ROS) and reduced mitochondrial ATP supply (Frugier et al., 2015)

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Gluteq sublingual oral spray eliminates the first-pass effect of the liver, has better bioavailability, hence higher efficacy

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Gastrointestinal effects represent the most common concern: Nausea and vomiting : May be pronounced when initiating either medication or during Wegovy dose escalation Diarrhoea or constipation : Both medications can affect bowel habits Reduced appetite : Wegovy's appetite-suppressing effects combined with SSRI-related nausea may significantly reduce food intake Abdominal discomfort : Bloating, dyspepsia, or gastric pain may occur To minimise gastrointestinal distress, consider taking escitalopram with food and following the gradual Wegovy dose escalation schedule precisely

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