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In the Exe-9-treated group, a negative correlation trend was observed between them following MC38 restimulation, although the trend was not statistically significant (r=0.6302

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However, the American Association of Endocrinologists (AACE/ACE) has recommended metformin for patients with prediabetes, insulin intolerance, and those who fail to respond to lifestyle modifications or anti-obesity medications

KN received honoraria from Astellas, AstraZeneca, Bayer Yakuhin, Boehringer Ingelheim Japan, Daiichi Sankyo, Eli Lilly Japan, Kowa, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical, MSD, Novartis Pharma, Novo Nordisk Pharma, Ono Pharmaceutical, Otsuka, and Teijin Pharma

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