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i , Six residues around the intracellular ionic lock of GLP-1R (H180 2.50b , L251 3.54b , L349 6.40b , S350 6.41b , T353 6.44b and Y402 7.57b ) were selected to calculate the solvent-accessible surface areas (SASA) using the program freeSASA 49
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It has been demonstrated that GLP-1 agonists significantly increase the mass of the femur and vertebrae (71)
2f is rate-limiting and no enzymesubstrate complexes accumulate in contrast to enzymes with typical MichaelisMenten kinetics 2,39,52
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