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The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board
Most patients require 2-4 sessions spaced 3-6 weeks apart for optimal results
Dose 1-2 hours before your largest or highest-calorie meal of the day
A 10 mg vial at 250 mcg per dose lasts forty doses, which will outlast the 28 day window on most protocols
Clinical studies demonstrating significant benefits typically use concentrations of 1 to 3%
Further, the semaglutide study had 9 participants that needed to reduce their dose or stop entirely, as compared to the liraglutide group, in which all participants maintained the same dose
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