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Generally administered once per week Requires comfort with self-injection Dose is typically increased gradually Can produce gastrointestinal side effects Ongoing treatment may be needed to maintain benefits Which Weight Loss Option Fits Your Goals

Healthcare providers must consider these factors when prescribing semaglutide to patients on gender-affirming HRT

November 24, 2025

Metabolic pathways GLP-1 (S) Semaglutide GLP-1 receptor agonist analogue A long-acting analog of human glucagon-like peptide-1 with extensive published literature across glycemic, weight, and cardiovascular research endpoints

The review showed that dulaglutide is also a cost-effective option for patients with T2D when compared to liraglutide

We cover the specifics in Is Compounded Semaglutide Still Legal in 2026