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Till date, eight different isozymes, viz., GPx1-GPx8, have been identified in humans, of which GPx1, GPx2, GPx3, GPx4, and GPx6 are selenoenzymes containing Sec in their active site (Table 1) [1, 8, 9]

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JAMA, 321(15), 1466-1480

Further, it was revealed that the increased synaptic transmission was blocked by PI3k inhibitors, indicating that this effect is dependent on PI3k activation [9]

Therefore, pancreatic -cell sensitivity to both glucose and incretin hormones is essential for maintaining glucose homeostasis