however, MADRS did not change significantly
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This indicates the existence of a GGCT-mediated Gln metabolic shunt in tumor cells: Gln is prioritized for conversion to GSH, which scavenges ROS, alleviates oxidative stress, and ultimately promotes tumor cell proliferation
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Nevertheless, two placebo-controlled crossover studies demonstrated that 2 months of folate supplementation improves endothelial function in hyperhomocysteinemic subjects by decreasing homocysteine levels (Bellamy et al, 1999