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PubMed CrossRef Salvi V, Mencacci C, Barone-Adesi F
If you are on the maximum dose of semaglutide (2.4 mg for Wegovy) or tirzepatide (15 mg for Mounjaro), your peak drug levels are already near the top of the therapeutic range
10.1007/s00401-012-0954-z 35
Additionally, PC1/3 is expressed in -cells but at lower levels than PC2, and the ratio of GLP-1 to glucagon expressed in islet cells has been shown to be increased during the progression of diabetes (OMalley et al., 2014)
And if you're drinking for several hours, you're likely not drinking much water to top it up either
