But as with any treatment, it comes with both benefits and drawbacks
Your GLP-1 receptors can become less sensitive after months of constant stimulation, your metabolism adapts downward as you lose weight, and lifestyle factors that weren't problems at higher weights start to matter more
This is especially important for individuals with diabetes, as any supplement claiming metabolic effects requires medical oversight to ensure it does not interfere with established treatment regimens or mask concerning symptoms requiring evaluation
The decision to continue, adjust, or discontinue therapy should be based on objective body composition measurements (DEXA scans, circumference measurements), achievement of fat loss goals, tolerance and side effect profile, and physician assessment of metabolic markers
These side effects of Semaglutide are more common during the first few weeks of treatment and typically resolve on their own
These SCFAs directly stimulate L-cells to release GLP-1 and PYY, both of which contribute to satiety signaling