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Small uncontrolled step-down and reduced-frequency series also suggest that some users can hold a plateau with less exposure, but no randomized trial has tested reducing stable 2.4 mg users into this band
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Along with wide exposure of copper on the skin or mucosa, incidences of contact dermatitis have been reported although not frequently
There are no large controlled human trials establishing combined efficacy or safety, and the pairing remains a subject of ongoing preclinical interest rather than clinical fact
The injection bypasses the digestive system, meaning food intake does not affect its absorption or efficacy
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