More recently, a phase 2 trial published in the New England Journal of Medicine showed that high-dose semaglutide (2.4 mg weekly) achieved NASH resolution without worsening of fibrosis in 59% of patients versus 17% with placebo
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However, the effect was not clearly reproducible and only occurred in certain individuals
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After age 3540, many individuals begin experiencing: Reduced muscle recovery Loss of lean muscle mass Increased soreness Slower healing Reduced exercise resilience Chronic inflammation and oxidative stress contribute significantly to muscle decline