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This biosynthesis perfectly mimics how green tea leaves naturally produce theanine, guaranteeing a 100% pure L-isomer product entirely free of the competing D-isomer
Thus, the interaction with p300 prevents the MDM2-mediated proteasomal degradation of p53
For many people, a combination approach is highly effective
To adjust the pH, 2 L of Tris-HCl pH 7.5 was added along with 12.5 L of premixed NuPAGE LDS Sample Buffer (Thermo Fisher Scientific #NP0007), and the samples were stored at 20 C
Front Pharmacol 13:1034515
Science 353, 11611165
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