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Peer review Peer review information Nature Medicine thanks Victor Volovici, John Wilding and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
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Furthermore, in signaling studies that used cell lines with recombinantly expressed human GIPR or GLP-1R, tirzepatide stimulated cyclic adenosine monophosphate (cAMP) accumulation by either receptor with potency similar to that of native GIP and approximately 13-fold weaker than that of native GLP-1 [1]
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