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Use this visit to ask about alternatives, interactions (such as oral contraceptives), and how success will be measured

Specifically, studies suggest that muscle loss with GLP-1s can range from 25 to 39 percent of the total weight loss while muscle loss via caloric restriction (with less total weight loss) ranges from 10 to 30 percent

Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J, et al

A specialist eventually advised her to discontinue Ozempic, and after doing so, her symptoms resolved

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The STEP UP Phase 3b clinical trial, published in The Lancet Diabetes and Endocrinology in 2025, enrolled over 1,400 adults with obesity and without diabetes