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This is the same logic that makes the sildenafil-nitrate combination contraindicated: the FDA label for Viagra states that "administration of Viagra to patients who are using organic nitrates in any form is contraindicated" because of "potentiation of the hypotensive effects of nitrates" [3]
doi: 10.1017/S0007114510004319 112 SavignacHTramullasMKielyBDinanTCryanJ
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This process involves the activation of the JNK and p38 MAPK signaling pathways (337, 338)
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