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Male mice lacking the entire Mc4r coding region were fertilized with oocytes from female C57BL/6J mice by in vitro fertilization (IVF) to generate heterozygous offspring of both sexes, which were subsequently intercrossed to obtain homozygous knockout mice

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SD consumption after an overnight fast was likewise suppressed by each treatment (Extended Data Fig

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Weight 4813.5 g/mol Sequence / Formula Dual GIP / GLP-1 receptor agonist Journal In-depth Read our in-depth article on Tirzepatide what's proven, what isn't