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Long-acting agents (e.g., semaglutide weekly, dulaglutide weekly) provide sustained receptor activation, improving both fasting and postprandial glucose

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Someone with a genetic variant affecting iron absorption might benefit from a higher-dose iron supplement or more frequent dosing, while another patient's genetics might indicate stronger calcium needs

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Women of childbearing age should use reliable contraception while on semaglutide and stop the medication at least two months before trying to conceive

For older patients, those with existing sarcopenia, or those on aggressive caloric restriction, more frequent monitoring (every 34 weeks) is advisable during the dose escalation phase