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They therefore manipulated two enzymes called proprotein convertase 2 (PC2), which is responsible for boosting glucagon production, and proprotein convertase 1 (PC1), a producer of GLP-1 in intestinal cells and pancreatic alpha cells

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One of the most compelling pieces of evidence comes from the Requpero study by Barletta et al

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Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine .