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If a higher or more frequent dosage is required, the cost can increase, especially if the treatment plan is personalized to optimize results

The reimbursement policy impact is substantial, with stringent prior authorization requirements and step-therapy protocols limiting access

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Canada: The Canadian patent (CA 2,675,150) expires December 2028, with no patent term extension granted

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Saliva is essential to oral health as it helps swallowing, talking and taste, and protects the mouth and teeth