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21 In addition, there were also increased levels of proinflammatory cytokines, such as IL-1, TNF-, and IL-17, which correlated with an increased production of free radicals

This simply contributes to our body staying fit for the long term

This may explain why p21 overexpression alone was not sufficient to fully inhibit ferroptosis in our hands: p53 stabilization is needed together with p21 induction for complete inhibition of RNR complex expression and function

There are many potential processes underlying MTX toxicity (Reference Chan and Cronstein33) , but no effective treatments to ameliorate the condition exist