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Here are the most common symptoms: Fatigue: Feeling excessively tired or lethargic, even after a full nights rest

[3] Controlled evidence demonstrating clinically meaningful weight loss from these injections is lacking

Novo Nordisk filed a New Drug Application for the CagriSema combination (cagrilintide 2.4 mg + semaglutide 2.4 mg) in December 2025, with an FDA decision anticipated in late 2026

STAT News reports that under normal circumstances the final decision would be made by FDA scientists, but its possible that Trump administration officials could intervene and overrule them