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As newer, more effective compounds receive approval in other jurisdictions, pressure may build for faster Canadian regulatory review of obesity medications specifically

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Tirzepatide's GIP co-agonism appears to protect against diarrhea relative to semaglutide, even at higher weight loss

All clinical trials use subcutaneous injection

Polymorphisms in GLP-1 receptor genes, incretin pathway enzymes, and appetite regulation circuits influence individual response

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