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Martinez-Outschoorn UE, Lin Z, Trimmer C, Flomenberg N, Wang C, Pavlides S et al
Microglia with the M1 phenotype can show signs of inflammation under specific environments whereas those with the M2 phenotype generally do not
Evidence oxidant stress
(Nature, 2004) reported that T4 improves cardiomyocyte survival and post-infarction cardiac function in murine models, with an anti-fibrotic effect
Consequently, wild-type p53 suppresses NADPH production, whereas tumor-associated p53 mutants show almost no activity in inhibiting G6PD, thereby maintaining a high level of NADPH production
10.1038/nrd.2015.6 23 CrawfordR
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