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Prenatal exposuresincluding fever, infections, and medications like Tylenolmay contribute for some children, especially in the context of specific genetic profiles and co-exposures

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The effects of FGF23 are exerted primarily within the kidney where its actions result in increased phosphate excretion (decreased phosphate reabsorption) and suppression of calcitriol synthesis via inhibition of the expression of the CYP27B1 gene that encodes the PTH-inducible 1--hydroxylase enzyme

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It acts by inhibiting mitochondrial complex I, which reduces ATP production, which results in compensatory upregulation of glycolysis, secondary lactate production, and oxidative stress [434]

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