Kaplan A, Kochetova A, Nezavibathko V, et al
Tirzepatide is a dual-agonist peptide researched for its interaction with both GLP-1 receptors and GIP receptors
Null variants (frameshift, nonsense, large deletions), which lead to a completely non-functional protein, are usually associated with PFIC [19]
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Its defining chemical feature, and the reason it is studied as a complex, is its high affinity for copper(II)