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The most common reasons are documentation deficiencies (missing BMI or comorbidity records), step therapy requirements (you haven't tried a required prior medication), structural coverage exclusion (your plan doesn't cover GLP-1s for obesity), or indication mismatch (you were prescribed Ozempic for weight loss when only Wegovy is approved for that use)

However, during long-term or high-dose VPA therapy, or after acute VPA overdose, a greater degree of -oxidation occurs, potentially increasing the risk for toxicity

Weight regain typically occurs within 12 months of stopping, making long-term or ongoing use the most effective strategy for sustained results

Your prescribing provider must know about all steroid use, including inhaled corticosteroids for asthma, topical steroids for skin conditions, and any recent steroid injections for joint pain

Reduces hunger: The higher your blood sugar is, the hungrier you feel

Key clinical nuance: MASH patients often carry significant cardiometabolic burden