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Introduction Dry eye (DE), identified as one of the most prevalent ocular surface diseases, manifests through tear film instability, hyperosmolarity, chronic inflammation, and a spectrum of ocular discomfort symptoms [1, 2]

In the absence of PKR, intestinal epithelial cells show impaired survival and proliferation, which exacerbates intestinal inflammation (100)

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Injectable tirzepatide is a weekly weight-loss injection that patients administer themselves with a small needle, typically in the stomach, thigh, or upper arm

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Tirzepatide, a dual GLP-1 and GIP receptor agonist, produces slightly faster cumulative losses (1522% body weight vs