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The established tight inverse relationship between stroke volume and heart rate in POTS in which tachycardia functions as a compensatory response to inadequate stroke volume rather than a primary dysrhythmia indicates that pharmacological perturbations that reduce venous return or peripheral vascular tone are likely to be hemodynamically consequential in this population (Sheldon et al., 2019)

Nat Commun 15 , 8498 (2024)

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