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PLoS ONE 6 , e17706e17706 (2011)
GLP-1 receptors are expressed in the afferent branch of the vagus nerve and the enteric nervous system (ENS)
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If using both in the same routine, wait 15 to 20 minutes between applications
Standard ice packs can freeze medication if they contact the pen directly, so choose cases with barriers between the cooling element and the medication
Then in May 2022, the FDA approved tirzepatide (Mounjaro) for type 2 diabetes the first GIP/GLP-1 dual agonist, hitting two incretin receptors at once and producing larger A1c and weight effects in the SURPASS program than any prior single-mechanism GLP-1
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