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Because the majority of the -cells do not express GLP-1R, and also because GLP-1 inhibits glucagon secretion even in T1D patients with low insulin pancreatic reserve, the mechanism by which GLP-1 decreases glucagon secretion is still a matter of debate [15]
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Trends Pharmacol Sci 2018;39:36786.ArticlePubMed 45
Singh M, Jadeja SD, Vaishnav J, Mansuri MS, Shah C, Mayatra JM, et al