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If supplement-related

Vitamin B12 deficiency in dogs can often be traced back to issues concerning the gastrointestinal (GI) tract

In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins

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It works by increasing levels of vitamin B12 in conditions in which it is necessary