Many peptides have excellent safety profiles for extended use when properly monitored
Studies using a high-fat diet (HFD) induced obesity mice model characterized by decreased serum T levels, impaired sperm quality, and increased testis inflammation, showed that exenatide administration was able to reduce body weight and improve the quality of sperm without increasing serum T levels but lowering the expression of proinflammatory cytokines (25)
Notably, there is a well-established association between exposure to ionizing radiation, particularly during childhood, and an increased risk of developing PTC (Su et al., 2016)
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Temporary worsening after GLP-1 RA initiation doesnt necessarily imply that GLP-1 RAs are harmful to the eye or should be discontinued