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FIGURE 12 4.1.1 Imidazo[1,2-a] pyrazine derivatives An HTS campaign and subsequent structural optimization of Compound 37 , an initially identified PDE10A inhibitor, led to the discovery of imidazo[1,2-a] pyrazine-containing Compound 40 , a potent and selective PDE10A inhibitor exhibiting promising in vivo efficacy across various rodent behavioral models of schizophrenia, along with favorable pharmacokinetic properties in rats