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by slowing antro-duodenal transit of nutrients

Some animals in the ML162 treated group were excluded from the toe spreading assay because they developed a toe-biting phenotype, which is known to associate with sciatic nerve surgery in rodents 108

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Following this exclusion process, we conducted a quantitative analysis of the remaining adverse events (AEs), ranking them by reporting frequency and selecting the top 50 PTs for detailed evaluation (Fig