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CrossRef Efficacy and Safety of Pregabalin and AlphaLipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, OpenLabel, NonInferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study) Tae Jung Oh, Sang Soo Kim, SeungHwan Lee, HyukSang Kwon, Eun Sook Kim, EunJung Rhee, Hye Jin Yoo, Han Na Jang, Woo Je Lee, Eun Sook Kim, Sang Yong Kim, Gwanpyo Koh, EunGyoung Hong, Tae Sun Park, Jong Chul Won Diabetes, Obesity and Metabolism.2026

This work was also supported by the Nicolaus Copernicus University IDUB programme through funding awarded to the FemLife_OMICS Research Team for Women's Health Across the Lifespan

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This suggests AHK-Cu primarily protects existing DPCs from death rather than simply making them multiply faster an important distinction for treating hair loss where follicle miniaturisation involves progressive cell loss