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Abbreviations AASS: Alpha-aminoadipic semialdehyde synthase AD: Alzheimers disease ALDH1L2: Mitochondrial 10-formyltetrahydrofolate dehydrogenase Alpha-KGDH: Alpha-ketoglutarate dehydrogenase ALS: Amyotrophic lateral sclerosis ATP: Adenosine triphosphate CoA: Coenzime A DMEM: Dulbecco's modified eagle medium DNA: Deoxyribonucleic acid FBS: Fetal bovine serum FOXN4: Forkhead box protein N4 hnRNPA/B: Heterogeneous nuclear ribonucleoprotein A/B HRP: Horseradish peroxidase ICP-MS: Inductively coupled plasma mass spectrometry LPO: Lipid peroxidation MDA: Malondialdehyde mtACP: Mitochondrial acyl carrier protein NADH/NAD + : Nicotinamide adenine dinucleotide NBIA: Neurodegeneration with brain iron accumulation NF-Y: Nuclear transcription factor Y NFS1: Cystine desulfurase OXPHOS: Oxidative phosphorylation system PANK2: Pantothenate kinase 2 PBS: Phosphate buffer saline PD: Parkinsons disease PDH: Pyruvate dehidrogenase PGC-1alpha: Peroxisome proliferator-activated receptor-gamma coactivator PKAN: Pantothenate kinase-associated neurodegeneration PPGC-1alpha: Phospho Peroxisome proliferator-activated receptor-gamma coactivator PUFAs: Polyunsaturated fatty acids ROS: Reactive oxygen species SDS: Sodium dodecyl sulfate STF: Streptomycin TFAM: Transcription factor A 4-HNE: 4-Hydroxynonenal References Gregory A, Polster BJ, Hayflick SJ

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Scientists studying endocrine communication often investigate peptide combinations to better understand how multiple receptor pathways interact within controlled experimental environments