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The fusion peptide demonstrated sleep-promoting effects, influenced neurotransmitter levels (5-HT, glutamate, dopamine, melatonin), and confirmed that the Tat cell-penetrating sequence was the more effective BBB carrier of two tested candidates establishing DSIP as a validated active scaffold for BBB-crossing fusion peptide sleep research and supporting the development of next-generation DSIP-based neuromodulatory tools

Cells are pretreated with DMSO, JQ1 (10 M), MLN4924 (1 M) or carfilzomib (500 nM)

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Simultaneously, AHK-Cu improves the vascular environment that feeds dermal scalp tissue, ensuring that the raw materials for repair are efficiently delivered at the cellular level